Well, the only difference I've noticed is that, on some games (like Chrono Trigger and Secret of Evermore - both made in Mexico, though Evermore also had a Made in Japan version), it depends on where they were made...made in Japan games seam to have better-quality boxes. I noticed that on sealed copies of Chrono Trigger and Secret of Evermore...if you look very closely near where you'd open the game and pull the materials out (right side of the box when looking at the front cover), the box has tiny "creases" or "white lines" that make it look as if the game were previously opened. Secret of Mana, FF2, and FF3 (at least copies that I've seen) do not have this, and from wht I remember, they were all Made iin Japan..